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Over the past few years, there has been an explosion of data science as a profession and an academic field. The increasing impact and societal relevance of data science is accompanied by important questions that reflect this development: how can data science become more responsible and accountable while also responding to key challenges such as bias, fairness, and transparency in a rigorous and systematic manner? This Patterns special collection has brought together research and perspective from academia, the public and the private sector, showcasing original research articles and perspectives pertaining to responsible and accountable data science.